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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SCN2A All Species: 28.48
Human Site: Y1975 Identified Species: 62.67
UniProt: Q99250 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q99250 NP_001035232.1 2005 227975 Y1975 S T T S P P S Y D S V T K P E
Chimpanzee Pan troglodytes XP_001153227 2005 227953 Y1975 S T T S P P S Y D S V T K P E
Rhesus Macaque Macaca mulatta XP_001099608 2005 228017 Y1975 S T T S P P S Y D S V T K P E
Dog Lupus familis XP_858129 2006 227947 Y1976 S T T S P P S Y D S V T K P E
Cat Felis silvestris
Mouse Mus musculus Q62205 1984 225794 S1955 A S T I S P P S Y D S V T K P
Rat Rattus norvegicus P04775 2005 227855 Y1975 S T T S P P S Y D S V T K P E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512686 2008 228349 Y1978 S T T S P P S Y D S V T K P E
Chicken Gallus gallus XP_422025 2006 228269 Y1976 S T T S P P S Y D S V T K P D
Frog Xenopus laevis
Zebra Danio Brachydanio rerio Q2XVR3 1829 207718 E1799 G Q L I L P V E L T S E V I L
Tiger Blowfish Takifugu rubipres Q2XVR7 1892 213080 R1837 D E V E G L R R R P D P Q T R
Fruit Fly Dros. melanogaster P35500 2131 239344 D2057 A E G A A D A D E S N V N S P
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.8 99.8 98.6 N.A. 77.8 97.7 N.A. 95 92.2 N.A. 63.2 61.6 45.3 N.A. N.A. N.A.
Protein Similarity: 100 100 99.9 99.4 N.A. 86.8 98.9 N.A. 98 96.6 N.A. 74.9 74.5 62.2 N.A. N.A. N.A.
P-Site Identity: 100 100 100 100 N.A. 13.3 100 N.A. 100 93.3 N.A. 6.6 0 6.6 N.A. N.A. N.A.
P-Site Similarity: 100 100 100 100 N.A. 26.6 100 N.A. 100 100 N.A. 13.3 6.6 33.3 N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 19 0 0 10 10 0 10 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 10 0 0 0 0 10 0 10 64 10 10 0 0 0 10 % D
% Glu: 0 19 0 10 0 0 0 10 10 0 0 10 0 0 55 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 10 0 10 0 10 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 19 0 0 0 0 0 0 0 0 0 10 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 64 10 0 % K
% Leu: 0 0 10 0 10 10 0 0 10 0 0 0 0 0 10 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 10 0 10 0 0 % N
% Pro: 0 0 0 0 64 82 10 0 0 10 0 10 0 64 19 % P
% Gln: 0 10 0 0 0 0 0 0 0 0 0 0 10 0 0 % Q
% Arg: 0 0 0 0 0 0 10 10 10 0 0 0 0 0 10 % R
% Ser: 64 10 0 64 10 0 64 10 0 73 19 0 0 10 0 % S
% Thr: 0 64 73 0 0 0 0 0 0 10 0 64 10 10 0 % T
% Val: 0 0 10 0 0 0 10 0 0 0 64 19 10 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 64 10 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _